RNA Details
Disease Name
Pulmonary Disease Chronic Obstructive
Tissue
lung
RNA Symbol
CXCL8
RNA ID
RNA Type
mRNA
Alteration Pattern
histone hyperacetylation
Species
homo sapiens
Detection Methods
qRT-PCR; HDAC activity assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
Year
2005
Function
Patients with COPD have a progressive reduction in total HDAC activity that reflects the severity of the disease; Specimens of lung tissue obtained from patients with increasing clinical stages of COPD had graded reductions in HDAC activity and increases in interleukin-8 messenger RNA (mRNA) and histone-4 acetylation at the interleukin-8 promoter.